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Brain Injury

Hyperbaric oxygen therapy and Brain Injury

HBOT Induces Cerebrovascular Changes & Improves Cognitive Function in a Traumatic Brain Injured Rat

Low pressure hyperbaric oxygen therapy ( LPHBOT ) Induces cerebrovascular changes and improves cognitive function in a rat traumatic brain injury (TBI) model.

Paul G. Harch, CL Kriedt, MP Weisend, KW Van Meter, R.I Sutherland, Baromedical Research Institute & LSU School of Medicine, New Orleans, LA 70114, and University of New Mexico Depts. of Psychology and Physiology, Albuquerque, NM 87131

: In 1996 pilot data were reported on this project [UHM, 1996, 23: (Suppl); 48]. The present study ia a replication of the cognitive improvements and blood vessel changes in that experiment using a larger number of rats.

METHODS: 42 adult male Long-Evans hooded rats were subjected to the unilateral weight-drop focal cortical impact model of TBI. 49 days following TBI, the ram underwent LPHBOT in 2 groups: (1) 80 bid 13 ATA/90 HBOTs (n=l 9); (2) 80 bid sham air treatments (n=23). Motor function and spatial memory tasks were assessed before and after HBOT. Animals were sacrificed, brains sectioned, stained with T,T-diaminobenzidine, and vessel density analyzed via computer assisted densitometry.

HOTFAST: Hyperbaric Oxygen Therapy for Acute Stroke

This study will be conducted in three phases. The first phase is a feasibility study that will entail entering a minimum total of 13 patients at all of the participating centers to assess the 'feasibility of completing the protocol as well as the safety issues involved. It will be an uncontrolled trial. The data from this study will be submitted to the NIH for the second phase, which would be a fully funded, randomized, prospective,
controlled-blinded trial. Should this second phase show positive results, it may stand alone or necessitate the third phase, a much larger multicenter trial.