FW8-2

Generic inhibitory drug effect of hyperbaric oxygen therapy (HBOT) on reperfusion injury (RI)

P.G. Harch

LSU School of Medicine, New Orleans, LA, USA

Introduction HBOT is the use of high pressure 0₂ as a drug to treat pathophysiologic processes and their diseases. The purpose of this paper is to see if HBOT has a generic inhibitory drug effect on RI.

Methods Review of animal studies on HBOT in RI.

 

Results

____________________________________________________________

HBOTwith Respect
to Ischcmia                                                                                                         HBOT
                                                                                                Model                 Dose

Pre       During Post     Study               Date     Species Organ lschemia           Effect (ATA)

 

X          X          Thomas            '90       Dog      Heart    MI                      Ågr;   2.0

X          X          Zamboni           '93       Rat       Muscle Global                Ågr;   2.0

X          X          X          Thom               '93       Rat       Brain    CO                     Ågr;   .21; I,2,3
X          X          Yamada           95        Rat       IntestineGlobal               Ågr;   2.0

                        X         Mink                 '95       Rabbit  Brain    Air Embol           Ågr;   2.8

            X                      Atochin             '99       Rat       Brain    Stroke                Ågr;   23

 

 

Six models in 4 different organs and 3 species showed HBOT inhibition. One model used a dose response design and showed a positive effect.

Conclusion HBOTacts like a generic drug to inhibit RI by showing dose response and timing characteristics across multiple species/organs/ischemic models before, during, and within 1 h post ischemia at ≥ 2 ATA.